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Welcome : Award Global Pharmaceuticals Company Limited

We strive to deliver the highest quality pharmaceutical and services to the healthcare sector. We rely on this to drive our performance, which consequently ensures continued high returns both for us and you.



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Check out our new range of Products for your total wellness

MANAGING OXIDATIVE STRESS IN THIS AGE

INTRODUCTION

The human body is made up of different cells, tissues and organs. These components of the body work in harmony on a daily basis to keep the body healthy and strong. A  healthy body consists of  over 10trillion cells, while it equally have four specialised tissues namely - epithelial tissue, connective tissue, nervous tissue and muscle tissue.

POSITIVE EFFECTS:

The human body reacts with oxygen as it breathand its cells produce energy. As a result of this activity, highly reactive molecules are produced within cells known as FREE RADICALS.

NEGATIVE EFFECTS:

When the human body protein-controlled anti-oxidants does not keep up to its optimal capacity against these radicals, it leads to a condition called OXIDATIVE STRESS.

WHAT IS OXIDATIVE STRESS?

Oxidative stress reflects an imbalance between the systemic manifestation of the reactive oxygen species and a biological system’s ability to readily detoxify the reactive intermediates or to repair the resulting damage. Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipid and DNA.

INDUCTION OF OXIDATIVE STRESS

OXIDATIVE STRESS AND DISEASES

Aging, Cancers, Degenerative disorders: Alzheimer’s disease & Parkinson’s disease, Cardiovascular diseases: Atherosclerosis.

ILLUSTRATION OF OXIDATIVE STRESS EFFECTS

HEALTH IMPLICATIONS OF OXIDATIVE STRESS

This damage to cell and its components has been linked to several disease condition affecting human race today. Some of the conditions include:

                Diabetes             Alzheimer’s Disease

                Asthma               COPD

                Cancer                  Atherosclerosis

                HIV/AIDS, etc

OXIDATIVE STRESS AND AGING

OXIDATIVE STRESS AND CANCERS

Oxidative DNA modifications are frequent in mammalian DNA and appear to be important mechanisms in carcinogenesis, diabetes and ageing. Oxidative stress plays a multistep role in  carcinogenesis, through a process of both cell mutation and proliferation. 

OXIDATIVE STRESS AND PARKINSON’S DISEASE

OXIDATIVE STRESS AND ALZHEIMER’S DISEASE

OXIDATIVE STRESS AND DIABETES

Both types of diabetics display increased levels of reactive oxygen species such as free radicals; for this reason ,the onset of diabetes is closely associated with oxidative stress(1,2)

Oxidative Stress Pathway in Diabetes mellitus

Diabetic oxidative stress and organ effects.

OXIDATIVE STRESS AND ATHEROSCLEROSIS

OXIDATIVE STRESS AND COPD

Oxidative stress damages and impairs the functioning of the several kinds of proteins, harming lung physiology in ways that can induce COPD. The harmful effects include oxidative inactivation of anti-proteases and surfactants, excessive secretion of mucus, membrane lipid peroxidation, mitochondrial respirations, Alveolar epithelial injury, remodelling of the extracellular matrix and apoptosis.(3) Excercise causes increased oxidative stress in COPD patients, as in healthy people, but additional oxidative stress causes inflammation, and inflammation causes more oxidative stress.(4)

OXIDATIVE STRESS AND ASTHMA

Researchers are investigating the role of that an imbalance of oxidants and anti-oxidants(oxidative stress) plays in the development of chronic airway inflammation in asthma. In asthma, oxidative stress plays a strong role in the inflammation of airways and hyperactivity.(6)

OXIDATIVE STRESS AND CARDIOVASCULAR DISEASE

Oxidative stress has been associated with diverse diseases including cancer , renal disease, and neurodegeneration.Forty years of research also shows that all vascular cells produce reactive oxygen species, the by-products of oxidative stress, and that contributes to many of the abnormalities associated with vascular disease including atherosclerosis and hypertension(5)

OXIDATIVE STRESS AND HIV

HIV infection increases the oxidative stress process, and antiretroviral combination therapy increases protein oxidation and pre-existent oxidative stress. There is also a deficiency of glutathione in HIV infection. Persistent  oxidative load leads to an accelerated rate of  consumption of glutathione(GSH) in HIV infected patients.(7)

WHAT IS GISOMULT-PLUS™?

Gisomult-Plus™ is a multivitamin and mineral capsule fortified with

                High strength Panax ginseng        Lecithin

                Selenium             Alpha  lipoic acid(ALA)

GISOMULT-PLUS ™ AS A THERAPEUTIC ANTIOXIDANT

 ALPHA LIPOIC ACID(ALA)

This is a universal anti-oxidant known in nature. It is the only anti-oxidant that has affinity for both hydro and lipid environments. Vitamins C and E can only function in hydro and lipid environment respectively.

 BENEFITS OF ALPHA LIPOIC ACID

  •                 Reduces oxidative stress in the body via powerful antioxidant activity.
  •                 Improves several components of the metabolic syndrome a combination of  risk factors that increases one’s risk for diabetes.
  •                 Increases insulin sensitivity.
  •                 Improves diabetic neuropathy.
  •                 Protects against cataract formation.
  •                 Helps prevent retinal death when combined with vitamin E in retinitis pigmentosa.
  •                 Reduces brain damage after a stroke.
  •                 Prevents bone  loss, possibly through an anti-inflammatory effect.

BENEFITS OF SELENIUM

  •                 Aids in many of the metabolic pathways in human body. 
  •                 Benefits the skin during burn injuries.
  •                 Improves the immune system against cancer cells, herpes virus, cold sores and shingles.
  •                 Improves HDL cholesterol for a healthy heart.
  •                 Reduces risk of hospitalisation and prevent increases of HIV-1 viral load leading to increase in CD4 cells.

BENEFITS OF PANAX GINSENG

Gisomult-Plus has a high level of Panax ginseng 40mg which is the best quality ginseng in nature.

  •                 Ginseng boosts the immune system.
  •                 Improves mood and endurance.
  •                 Alleviates menopausal symptoms.
  •                 Enhances sexual performance.
  •                 Eliminates fatigue and general body weakness

BENEFITS OF LECITHIN

  •                 Improves brain function as it is a major source of choline which  is referred to as “brain food”
  •                 Facilitates movement of fats ,wastes ,nutrients and ions in and out of the cells.
  •                 Choline is especially important  for preventing memory loss from old age.
  •                 Essential for liver health by keeping liver fats dispersed in water.

CONCLUSION

Gisomult Plus is a well-balanced health supplement that could be co-prescribed as an adjunct in all disease conditions to facilitate recovery and healing.

Hence, ONE CAPSULE A DAY IS LIFE INSURED

Our Partners

Olive Healthcare Ltd – India
Medico Remedies PVT L td – India
SakarHealthcare PVT Ltd – India
Syncom Formulations PVT Ltd –India
GujaratLiquiPharmaceutical PVT Ltd – India
Noble Laboratories PVT Ltd- India

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